Depersonalization/Derealization Disorder (DPDR) is a dissociative condition marked by persistent or recurrent feelings of detachment from oneself (depersonalization) or the environment (derealization), often triggered by trauma, chronic stress, or substance use, and typically managed through psychotherapy—especially cognitive behavioral therapy (CBT), psychodynamic therapy, and trauma-focused approaches like EMDR—complemented by medications such as SSRIs for co-occurring anxiety or depression, and holistic practices like mindfulness, yoga, and grounding techniques, with residential rehab centers offering comprehensive care including individual, group, and family therapy, medical support, and lifestyle interventions to promote long-term recovery .